Inside every plant, animal and human cell there are billions of molecular machines. They are made up of proteins, DNA and other molecules, but no single element works alone. Only by observing how they interact with each other, in millions of types of combinations, can we begin to truly understand the processes at work in life.
In an article published in Nature, we present AlphaFold 3, a revolutionary model that can predict the structure and interactions of all the molecules of life with unprecedented accuracy. For protein interactions with other types of molecules, we see at least 50% improvement over existing prediction methods, and for some significant interaction categories, prediction accuracy has doubled.
We hope that AlphaFold 3 will support transform our understanding of the biological world and drug discovery. Researchers can access most of its capabilities for free with our newly launched solution AlphaFold server, easy-to-use research tool. To harness the potential of AlphaFold 3 in drug design, Isomorphic laboratories is already working with pharmaceutical companies to apply it to real-world drug design challenges and ultimately develop modern life-changing treatments for patients.
Our modern model builds on the foundations of AlphaFold 2, which in 2020 made a fundamental breakthrough in protein structure prediction. So far, millions of researchers around the world have used AlphaFold 2 to make discoveries in fields such as malaria vaccines, cancer treatments and enzyme design. AlphaFold has been cited over 20,000 times and its scientific impact has been recognized with numerous awards, most recently Breakthrough Award in Life Sciences. AlphaFold 3 takes us beyond proteins to a broad spectrum of biomolecules. This leap could unlock more transformative science, from developing biorenewable materials and more resilient crops to accelerating drug design and genomic research.