During severe treatment Burn and injuries, skin regeneration can be a matter of life or death. Extensive burns are usually treated by a slender layer of the epidermis, the upper layer of the skin, from other countries on the body. However, this method not only leaves vast scars, but also does not restore the skin to its original functional condition. While the skin of the skin, the skin is not regenerated, the layer below the epidermis, which contains blood and nervous vessels, cannot be considered normal skin.
Now the work of Swedish researchers could bring the medicine closer to the possibilities of regenerating live skin. They have developed two types of 3D bioprint techniques to artificially produce stout skin that is vascularized, which means that it contains blood vessels. One technique produces skin full of cells, and the other produces arbitrarily shaped blood vessels in the tissue. Two technologies take different approaches to the same challenge. The approaches are presented in two studies Published in the journal Advanced Healthcare Materials.
“The skin is so complicated that we can’t develop it in the laboratory. We don’t even know what all its elements are,” said Johan Junker, an associate professor at the Linköping University and a specialist in plastic surgery, who led this work Wawa statement. “That is why we and many others think that we could transplant building blocks and then allow the body to the skin itself.”
The junker and his team designed a bio-connecting called “μink”, in which fibroblasts-cells producing skin ingredients, such as collagen, elastin and hyaluronic acid-hoded on the surface of miniature sponge gelatin profits and enclosed in hyaluronic gel. By building this ink three -dimensional with a 3D printer, they were able to create a skin structure filled with high density cells in Wola.
In an experiment with a mice, scientists confirmed that live cells grew in fragments of tissues made of this ink, secreting collagen and rebuilding the components of the dermis. Fresh blood vessels also grew inside the transplant, which indicates that long -term tissue consolidation conditions were met.
Blood vessels play an extremely vital role in the construction of artificial tissues. Regardless of how many cells are bred to create a tissue model, without blood vessels, oxygen and nutrients cannot be transmitted evenly to all cells. And without blood vessels, as the tissue structure increases, the cells in the middle of the tissue die.
The research team also created a technology called Refreshing (redirecting freely floating hydrogel hydrogel), which allows the adaptable structure of blood vessels in artificial tissues by printing and laying the hydrogel threads by 98 percent of water. These threads are much more tough than ordinary gel materials and can maintain their shape, even after bound or braids. In addition, they also have the properties of shape memory that allow them to return to their original shape, even after crushing.